Here is a guide to the "madness" that will unfold over the next-three weekends.
The Villanova Wildcats celebrates after defeating the North Carolina Tar Heels 77-74 in the 2016 NCAA Men's Final Four National Championship game at NRG Stadium on April 4, 2016 in Houston, Texas.
In the East, defending champion Villanova is No. 1, followed by second-seeded Duke.
Northwestern also bolstered its NCAA tournament resume with a road win last month at one of the toughest places to play, taking out then-No. But regardless of who's in their region, the Wildcats would like to think they have to be the favorites. If they get past the first round, it will set up a matchup with former Southwest Conference rival Baylor (two schools separated by less than 100 miles) in Tulsa.
Also look out for the six seed in the region, SMU, as a potential dark horse. Sophomore guard Allonzo Trier (17.3 ppg) and 7-foot Finnish freshman Lauri Markkanen (15.6 ppg) have the talent to get them through the Elite Eight barrier.
CALIFORNIA (21-12) was among the NCAA Tournament's First Four Out and therefore will be a No. 1 seed in the National Invitation Tournament. But this year, perhaps more than others, at least one No. 1 seed could be determined.
"H$3 ere's the essence of Duke's case: The Blue Devils have beaten a ton of really good teams", the report noted.
Arizona ended the season with strong wins over UCLA and OR on consecutive nights. They'll be hungry to get back to the final.
The south is loaded and features three of the strongest teams in the nation.
Klay Thompson leads the Warriors in scoring in Wednesday's loss
Whether that will be in time to keep home court advantage is questionable. "That's what I'm thinking about at this point". Speaking to nba.com about the hyper-extended knee he suffered, he said: "It could have been a lot worse, I hurt my knee".
Semifinals: North Carolina over Butler, UCLA over Kentucky.
EXPERIENCE MATTERS: Of the last 22 players to win Most Outstanding Player honors at the Final Four, 18 of them were juniors or seniors. Not many are picking the Number-1 overall seeded Wildcats to repeat, but they will certainly be one of the biggest threats for the 2017 title in the nation.
MI was playing its second game since a scary mishap when its plane slid off the runway before takeoff.
Surely, though, no program first is bigger than this invitation to the Big Dance. He has served as the head coach for Duke University since 1980 and the team has had 12 Final Fours under him. Over 128 total games, the No. 8 seed has 64 wins and the No. 9 seed has 64 wins. Regardless, the Jayhawks are likely the team to come out of the Midwest.
MI earned a No. 7 seed in the NCAA tournament Midwest Region and will face No. 10 seed Oklahoma State (20-12) on Friday. We're going to play Villanova basketball for 40 minutes and if a team beats us, then we'll tip our hats to them. Their two toughest games were against Syracuse and North Carolina, and both were big losses for the Hawks.
Fifth-seeded Virginia has a chance to make a deep run.
Mount Saint Mary's will have one of the smallest players in the field in 5-foot-5 Junior Robinson, the Mountaineers' second-leading scorer at 14.1 points per game.
The worst odds for any of the top two seeds in the tournament is Louisville at 10-1, and there's a fairly sizable drop off from them, UCLA (10-1) and OR (15-1) to the rest of the field.